b3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia
نویسندگان
چکیده
Background-—Perturbed balance between NO and O2 . (ie, NO/redox imbalance) is central in the pathobiology of diabetesinduced vascular dysfunction. We examined whether stimulation of b3 adrenergic receptors (b3 ARs), coupled to endothelial nitric oxide synthase (eNOS) activation, would re-establish NO/redox balance, relieve oxidative inhibition of the membrane proteins eNOS and Na-K (NK) pump, and improve vascular function in a new animal model of hyperglycemia.
منابع مشابه
β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia
BACKGROUND Perturbed balance between NO and O2 (•-). (ie, NO/redox imbalance) is central in the pathobiology of diabetes-induced vascular dysfunction. We examined whether stimulation of β3 adrenergic receptors (β3 ARs), coupled to endothelial nitric oxide synthase (eNOS) activation, would re-establish NO/redox balance, relieve oxidative inhibition of the membrane proteins eNOS and Na(+)-K(+) (N...
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